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There was coevnin dose-related difference in the survival of rats at weeks. This observation that a sub-threshold dose can prolong the increase in free sphinganine caused by a higher dose has been confirmed in mice treated by oral gavage Enongene et al. Analysis of feed intake and degree of fungal contamination indicated a fumonisin B content of 8. This interaction was clear covenln a mycological analysis of maize harvested during Sydenham et al. In studies on maize Yoshizawa et al.
It is produced by strains of F. Therefore, coveni results of studies with these materials corroborate those of studies in which pure fumonisin B 1 was used. Conversely, the rate in Centane has remained consistently high in males, at 56 per The lesser toxicity of hydrolysed fumonisin B 1 in rat liver is not due to reduced absorption.
No hydrolysis products were found in urine, confirming that fumonisin was hydrolysed in the gut, probably by microbial degradation. Evidence of disruption of sphingolipid metabolism is an early indicator of exposure of horses to fumonisins.
In vervet monkeys Cercopithecus aethiops treated intraperitoneally with fumonisin B 2elimination was rapid and followed a bi-exponential pattern half-time, 18 minsimilar to that of the elimination of fumonisin B 1 half-time, 40 min. Maize meal infested with F verticillioides induced tumours in the oesophagus and stomach of rats and mice Li et al.
Such membrane changes occur preferentially in hepatocyte nodules, creating an environment for differential growth relative to the surrounding normal tissue. Riley 7Gordon Shephard 4 and Gerrit J. All developed cirrhosis, intraventricular cardiac thrombosis and nephrosis Kriek et al. The effects of heating on the stability of fumonisins during various food processing procedures have been studied.
Selected biochemical mechanisms for the toxicity of fumonisin B 1 in vitro in models in which the proposed biochemical action has been shown to be related to specific molecular events or physiological or toxic effects.